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AG Sugimoto

Molekulare Mechanismen der Umgebungswahrnehmung

Profil

Unser Labor will verstehen, wie Zellen ihre Umwelt wahrnehmen, z. B. die Verfügbarkeit von Sauerstoff. Dafür entwickeln wir modernste experimentelle und computergestützte Hochdurchsatzverfahren.

Ausführliche Informationen zu unserer Forschung sind auf der englischen Version unserer Homepage zu finden.

Veröffentlichungen

Isoform resolved measurements of absolute translational efficiency define interplay of HIF and mTOR dysregulation in kidney cancer
Yoichiro Sugimoto, and Peter J. Ratcliffe
bioRxiv 2021

Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6
Matthew E. Cockman, Yoichiro Sugimoto, Hamish B. Pegg, Norma Masson, Eidarus Salah, Anthony Tumber, Helen R. Flynn, Joanna M. Kirkpatrick, Christopher J. Schofield, and Peter J. Ratcliffe
Proceedings of the National Academy of Sciences 2022

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
Jessica K. Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S. Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P. Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker, and Axel Behrens
Nature Communications 2022

Using hiCLIP to identify RNA duplexes that interact with a specific RNA-binding protein
Yoichiro Sugimoto, Anob M. Chakrabarti, Nicholas M. Luscombe, and Jernej Ule
Nature Protocols 2017

A retained intron in the 3′‐ UTR of Calm3 mRNA mediates its Staufen2‐ and activity‐dependent localization to neuronal dendrites
Tejaswini Sharangdhar, Yoichiro Sugimoto, Jacqueline Heraud‐Farlow, Sandra M Fernández‐Moya, Janina Ehses, Igor Ruiz Mozos, Jernej Ule, and Michael A Kiebler
EMBO reports 2017

hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1
Yoichiro Sugimoto, Alessandra Vigilante, Elodie Darbo, Alexandra Zirra, Cristina Militti, Andrea D’Ambrogio, Nicholas M Luscombe, and Jernej Ule
Nature 2015

iCLIP: Protein–RNA interactions at nucleotide resolution
Ina Huppertz, Jan Attig, Andrea D’Ambrogio, Laura E Easton, Christopher R Sibley, Yoichiro Sugimoto, Mojca Tajnik, Julian König, and Jernej Ule
Methods 2014

Structure of the large ribosomal subunit from human mitochondria
Alan Brown, Alexey Amunts, Xiao Chen Bai, Yoichiro Sugimoto, Patricia C. Edwards, Garib Murshudov, Sjors H.W. Scheres, and V. Ramakrishnan
Science 2014

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs
Shobbir Hussain, Abdulrahim A. Sajini, Sandra Blanco, Sabine Dietmann, Patrick Lombard, Yoichiro Sugimoto, Maike Paramor, Joseph G. Gleeson, Duncan T. Odom, Jernej Ule, and Michaela Frye
Cell Reports 2013

Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
Boris Rogelj, Laura E. Easton, Gireesh K. Bogu, Lawrence W. Stanton, Gregor Rot, Tomaž Curk, Blaž Zupan, Yoichiro Sugimoto, Miha Modic, Nejc Haberman, James Tollervey, Ritsuko Fujii, Toru Takumi, Christopher E. Shaw, and Jernej Ule
Scientific Reports 2012

Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions
Yoichiro Sugimoto, Julian König, Shobbir Hussain, Blaž Zupan, Tomaž Curk, Michaela Frye, and Jernej Ule
Genome biology 2012

Poly(ethylene glycol)-lipid-conjugated antibodies enhance dendritic cell phagocytosis of apoptotic cancer cells
Urara Tomita, Satoshi Yamaguchi, Yoichiro Sugimoto, Satoshi Takamori, and Teruyuki Nagamune
Pharmaceuticals 2012